BMEG 5103. Design and Analysis of Experiments in Biomedical Research. 3 Hours.

An advanced course covering sample size estimation with power calculations, protection of vertebrate animals and human subjects, factorial design, multivariate analysis of variance, parametric and non-parametrics data analysis, Kaplan-meier analysis, and post-test correction of multiple comparisons as related to biomedical data. Prerequisite: MATH 2584 and BMEG 3653 or equivalents. (Typically offered: Irregular)

BMEG 5213. Tissue Mechanics. 3 Hours.

The purpose of this course is to introduce students to non-linear biomechanics of soft tissues such as skin, bladder, blood vessels, and the brain. Topics covered: Tissue mechanics: continuum biomechanics, tensor analysis, kinematics of continua, balance laws. Governing physics of mechanics as applied to soft tissues. Various constitutive relations will be discussed: linear elastic, hyperelastic, viscoelastic, poroelastic, and inelastic materials with internal variables. Cannot receive credit for both BMEG 4213 and BMEG 5213. Prerequisite: BMEG 2813 and BMEG 4623 or equivalents. (Typically offered: Irregular)

BMEG 5223. Genome Engineering and Synthetic Biology. 3 Hours.

Genome Engineering and Synthetic Biology provides an overview of contemporary topics in genome engineering and synthetic biology. This course will introduce a range of topics in synthetic biology and genome engineering using recently published literature and publicly available data sets and software. In this rapidly evolving field, an ethics discussion will be held at the end of the course on potential topics including human embryo editing, genomic data privacy, patent claims, and GMOs. Students may not receive credit for both BMEG 4983 and BMEG 5223. Prerequisite: BMEG 3653 or DASC 3213. (Typically offered: Spring)

BMEG 5253. Biologics: Next Generation Therapeutics and Their Purification. 3 Hours.

The course focuses on the production and purification of biologics including monoclonal antibodies, viral vectors, nucleic acids and other biotherapeutics. In particular, the course will focus on the fundamental thermodynamics principles as well as kinetic limitations involved in upstream harvesting and downstream purification. Applications of PCR, mass spectroscopy, electrophoresis, imaging and modeling tools during the production and purification of biologics will be discussed. Students may not receive credit for both BMEG 4253 and BMEG 5253. (Typically offered: Irregular)

BMEG 5313. Advanced Biomaterials and Biocompatibility. 3 Hours.

From Absorbable sutures to Zirconium alloy hip implants, biomaterials science influences nearly every aspect of medicine. This course focuses on the study of different classes of biomaterials and their interactions with human tissues. Prerequisite: BMEG 3634 and BMEG 4623 or equivalents. (Typically offered: Irregular)

BMEG 5413. Tissue Engineering. 3 Hours.

This course introduces Tissue Engineering approaches at genetic and molecular, cellular, tissue, and organ levels. Topics include cell and tissue in-vitro expansion, tissue organization, signaling molecules, stem cell and stem cell differentiation, organ regeneration, biomaterial and matrix for tissue engineering, bioreactor design for cell and tissue culture, dynamic and transportation in cell and tissue cultures, clinical implementation of tissue engineered products, and tissue-engineered devices. Students may not earn credit for both BMEG 5413 and BMEG 4413. Prerequisite: BIOL 2533 and BMEG 3824. (Typically offered: Irregular)

BMEG 5423. Regenerative Medicine. 3 Hours.

The course covers five broad areas: Biological and molecular basis for regenerative medicine, tissue development, regenerative medicine and innovative technologies, clinical applications of regenerative medicine, and regulation and ethics. Prerequisite: BIOL 2533 and BMEG 3824 or equivalents. (Typically offered: Irregular)

BMEG 5513. Biomedical Optics and Imaging. 3 Hours.

This course will provide students with a fundamental understanding of various biomedical imaging modalities. Topics will include: Basics of light-tissue interaction - absorption, fluorescence, elastic and inelastic scattering; Computational and analytical models of light propagation to quantify tissue optical properties; Optical imaging techniques - spectroscopy, tomography, and laser speckle with potential clinical applications; and Clinical imaging modalities and recent advances - X-ray, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Computed Tomography (CT), Ultrasound imaging, and Photoacoustic imaging. At the end of this course, students should have a good understanding of optical imaging, spectroscopy, and non-optical imaging modalities, specific anatomical sites that they are best suited for, and the trade-offs between imaging depth and resolution. Students may not receive credit for both BMEG 4513 and BMEG 5513. (Typically offered: Irregular)

BMEG 5523. Biomedical Data and Image Analysis. 3 Hours.

This course focuses on an introduction to image processing and analysis for applications in biomedical research. After a review of basic MATLAB usage, students will learn fundamental tools for processing and analyzing data from a variety of subdisciplines within biomedical engineering. Topics include: filtering, thresholding, segmentation, morphological processing, and image registration. Through exercises involving 1D, 2D, and 3D data, students will develop problem-solving skills and a knowledge base in MATLAB required for customized quantitative data analysis. Students may not receive credit for both BMEG 4523 and BMEG 5523. Prerequisite: Graduate standing. (Typically offered: Irregular)

BMEG 560V. Advanced Individual Study. 1-6 Hour.

Individual study and research of a topic mutually agreeable to the student and faculty member. Prerequisite: Graduate standing. (Typically offered: Irregular)

BMEG 570V. Advanced Special Topics. 1-6 Hour.

Consideration of current biomedical engineering topics not covered in other courses. Prerequisite: Graduate standing. (Typically offered: Irregular) May be repeated for up to 15 hours of degree credit.

BMEG 5713. Cardiovascular Physiology and Devices. 3 Hours.

Understanding etymology of disease while creating solutions and dedicated devices is the primary focus of biomedical engineering. This course describes an interdisciplinary approach of the clinical and engineering worlds to develop devices for treating cardiovascular disease. The first part of the course will be a thorough review of the relevant anatomic and physiological considerations important for developing devices. Understanding these considerations from an engineering perspective to inform device development will be the second part of the course. Students may not receive credit for both BMEG 4713 and BMEG 5713. Prerequisite: Graduate standing. (Typically offered: Irregular)

BMEG 5800. Graduate Seminar I. 0 Hours.

A weekly seminar series comprised of presentations by invited speakers and graduate students as well as didactic instruction in relevant topics including research ethics, authorship, biosafety and the use of animals in biomedical research. Prerequisite: BMEG 5801. (Typically offered: Fall) May be repeated for up to 0 hours of degree credit.

BMEG 5801. Graduate Seminar I. 1 Hour.

A weekly seminar series comprised of presentations by invited speakers and graduate students as well as didactic instruction in relevant topics including research ethics, authorship, biosafety and the use of animals in biomedical research. (Typically offered: Fall) May be repeated for up to 2 hours of degree credit.

BMEG 5810. Graduate Seminar II. 0 Hours.

A weekly seminar series comprised of presentations by invited speakers and graduate students as well as didactic instruction in relevant topics including professional development, career options, effective communication, technology transfer, clinical translation and intellectual property. Prerequisite: BMEG 5811. (Typically offered: Spring) May be repeated for up to 0 hours of degree credit.

BMEG 5811. Graduate Seminar II. 1 Hour.

A weekly seminar series comprised of presentations by invited speakers and graduate students as well as didactic instruction in relevant topics including professional development, career options, effective communication, technology transfer, clinical translation and intellectual property. (Typically offered: Spring) May be repeated for up to 2 hours of degree credit.

BMEG 5903. Entrepreneurial Bioengineering. 3 Hours.

The course introduces entrepreneurship, business model canvas, and lean start-up principles to the students with a focus on medical device customer discovery and technology commercialization. Graduate degree credit will not be awarded for BMEG 4903. Degree credit will not be awarded for both BMEG 4903 and BMEG 5903. (Typically offered: Irregular)

BMEG 5953. Fundamentals of Fracture and Fatigue in Structures. 3 Hours.

The course will cover the concepts of linear-elastic, elastic-plastic and time-dependent Fracture Mechanics as applied to fracture in a variety of materials, structures, and operating conditions. The examples will include fracture in large components such as aircraft, bridges and pressure vessels and also in bones and in soft materials and human tissue. Prerequisite: Graduate standing in Civil, Mechanical or Biomedical Engineering or consent of the instructor. (Typically offered: Fall and Spring)
This course is cross-listed with MEEG 5953, CVEG 5953.

BMEG 600V. Master's Thesis. 1-6 Hour.

Master's Thesis. Prerequisite: Graduate standing. (Typically offered: Irregular) May be repeated for degree credit.

BMEG 700V. Doctoral Dissertation. 1-6 Hour.

Doctoral Dissertation. Prerequisite: Graduate standing. (Typically offered: Irregular) May be repeated for degree credit.